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Tau - Labelled (Arg,Lys) 13C15N

Application

Quantification of human Tau isoforms in
preclinical or clinical samples

Specific labelling

Arginine: 13C6,15N4, >99%

Lysine: 13C6,15N2, >99%

Description

Microtubule-associated protein tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

This product is for research use only and is not intended for diagnostic or therapeutic use.

10 µg     >    400 €