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The mAbXmise quantification kits are intended to monitor the concentration of therapeutic monoclonal antibodies (mAbs) in samples from patients treated with these mAbs. The kit is a quantitative assay. The test can be performed on plasma (EDTA, heparin or citrate collection tubes) and serum. Assay results are intended to be used by healthcare professionals. Before use, it is important to carefully read the instructions provided with the product.
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mAbXmise monoclonal antibodies quantification kits are In Vitro Diagnostic Medical Devices for laboratory professional use and CE-IVD labeled for Europe by BSI. Assay results are intended to be used by healthcare professionals. The kits are designed to perform absolute quantification by LC-MS (Liquid Chromatography – Mass spectrometry) of specific therapeutic monoclonal antibodies (mAbs) in a patient sample. Assay results are intended to be used by healthcare professionals. Before use, it is important to carefully read the instructions provided with the product. The products are non-refundable. The mAbXmise Kit described has not been cleared by any regulatory entity for diagnostic purposes outside of Europe. Proteomics mAbXmise Kits are not available for sale in all countries.
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World Kidney Day is an annual global campaign aimed at raising awareness of the importance of the kidneys.
This event is a joint initiative of the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations – World Kidney Alliance (IFKF-WKA).
The theme of this year is “Kidney Health for All: Advancing equitable access to care and optimal medication practice”.
The main job of your kidneys is to remove toxins, metabolism waste and excess water from your blood by filtering the blood and producing urine.
Kidneys also help to control your blood pressure, to produce red blood cells and to keep your bones healthy.
Your two kidneys are located in the abdomen, under the rib cage, and are the size of a fist.
Chronic kidney disease (CKD) is a progressive and irreversible loss of kidney function over a period ranging from several months to several years.
The kidneys will no longer be able to carry out their function of filtering the blood, regulating its composition and secreting hormones.
This malfunction can lead to complications such as the accumulation of metabolic and water waste, anaemia and cardiovascular problems. Chronic renal failure is most often the consequence of another disease, in particular diabetes and high blood pressure.
The treatment of chronic renal failure varies according to the stage of the disease, its origin and the particularities of each patient.
These include:
– Diuretics, which increase urine production
– Hypertensives, which reduce blood pressure
– Statins to control blood cholesterol levels
– Iron and erythropoietin derivatives to combat anaemia
– And many others!
When the capacity of the kidneys is reduced by 85%, dialysis or a kidney transplant is essential!
After the transplant, medication is prescribed for the rest of the patient’s life to prevent rejection: these are known as immunosuppressants.
At Promise Proteomics, we believe it is essential to provide patients with personalised treatment. We decided to create solutions for clinicians to quantify biotherapies in patient blood. The goal is to give to clinicians insightful data to monitor treatment and potentially adjust medication dosages, for each patient.
Some people are transplanted directly without dialysis; others are transplanted after several years of dialysis; still others return to dialysis if a transplant is rejected and they are waiting for a new transplant. Some people are on dialysis for the rest of their lives.
References
www.worldkidneyday.org
https://www.vidal.fr/maladies/reins-voies-urinaires/insuffisance-renale-chronique/traitements.html
https://fondation-du-rein.org/la-maladie-renale-chronique/
PROM-0017.V01-02.24
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