Therapeutic Drug Monitoring

Breakthrough technology to enhance monoclonal antibody-based treatment

Kit for Trastuzumab dosage

Application

Ready-to-use kit for implementation of Trastuzumab dosage.

No labelling

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Description
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PROMISE has developed a unique solution, dedicated to therapeutic drug monitoring of monoclonal antibodies, combining a full-length labelled trastuzumab standard, a generic preparation process for human serum preparation, and a targeted LC-MS approach. The complete solution developed by PROMISE allows to implement rapidly therapeutic monitoring of Herceptin® and biosimilars in your lab using LC-MS.

 

Reagents & Consumables provided:

  • Stable isotope labelled Tastuzumab -20µg
  • Consumables, reagents & solutions for sample preparation (trypsin not included).
  • Quality control: digested Trastuzumab light antibodies
  • Sample preparation protocol & LC-MS methods.

 

Solutions & Equipments required: 

  • Solvents for LC-MS analysis: formic acid, acetonitrile.
  • Trypsin
  • Vacuum manifold + pump (suited for 96 well plates)
  • Speed-vacuum or gas evaporator
  • 37°C oven or thermomixer (for sample digestion).
  • LC-MS instrument